Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
USERS' SCORE
Good
Based on 15 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Nattokinase (2,000 FU) (enzyme from Natto Extract) (Non-GMO soy derived)
100 mg
**
Top Medical Research Studies
9.5
We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Read More
8
We designed a study to explore the effectiveness of nattokinase in treating acute myocardial infarction, a condition often caused by blood clots. Thrombus formation leads to reduced blood flow, and finding effective treatments is critical for improving outcomes in heart attack patients.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Read More
Most Useful Reviews
9
Cardiovascular support
12 people found this helpful
Nattokinase is an excellent supplement for preventing heart attacks and strokes. For nine years, I have taken it and highly recommend it, especially after having experienced a heart attack and numerous TIA strokes. It is a reliable choice for supporting cardiovascular health.
Read More
9
Relieves heart pain
6 people found this helpful
After experiencing dull chest aches post-covid vaccinations, I began taking one capsule of nattokinase daily. I'm relieved the discomfort has vanished, particularly when lying on my right side. Although I didn’t get tests done, the improvement was noticeable, and I also take omega-3 supplements alongside it.
Read More
9
Heart health support
3 people found this helpful
Excellent product at a great price from Iherb! I was recommended Now brand Nattokinase for heart health by my doctor, who takes it himself. Iherb offers it at half the price of my local store, with speedy delivery. Highly recommend this product and shopping at Iherb.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
- All Researches
9.5
We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Read More
8
We designed a study to explore the effectiveness of nattokinase in treating acute myocardial infarction, a condition often caused by blood clots. Thrombus formation leads to reduced blood flow, and finding effective treatments is critical for improving outcomes in heart attack patients.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cardiovascular support
12 people found this helpful
Nattokinase is an excellent supplement for preventing heart attacks and strokes. For nine years, I have taken it and highly recommend it, especially after having experienced a heart attack and numerous TIA strokes. It is a reliable choice for supporting cardiovascular health.
Read More
9
Relieves heart pain
6 people found this helpful
After experiencing dull chest aches post-covid vaccinations, I began taking one capsule of nattokinase daily. I'm relieved the discomfort has vanished, particularly when lying on my right side. Although I didn’t get tests done, the improvement was noticeable, and I also take omega-3 supplements alongside it.
Read More
9
Heart health support
3 people found this helpful
Excellent product at a great price from Iherb! I was recommended Now brand Nattokinase for heart health by my doctor, who takes it himself. Iherb offers it at half the price of my local store, with speedy delivery. Highly recommend this product and shopping at Iherb.
Read More
9
Eases heart problems
1 people found this helpful
Excellent! It effectively thins the blood and alleviates my heart problems, particularly regarding blood pressure.
Read More
9
Promotes heart health
Modern studies indicate that nattokinase fosters heart and circulatory health by supporting normal blood clotting.
Read More
Frequently Asked Questions
7.5
Improves circulation
6 people found this helpful
Nattokinase significantly helps with circulation; since taking two daily, I've noticed a difference after a month. It's now more challenging to reach my desired heart rate during exercise, indicating a positive change in my overall cardiovascular health.
7.5
Improves blood circulation
9 people found this helpful
I took Nattokinase 100 mg for my mum to enhance heart health and blood circulation, maintaining normal blood clotting function. It dissolves blood clots, reduces their risk, lowers blood viscosity, and decreases bad cholesterol. I will provide an update after a few weeks.
6
Positive health shifts
The father takes it regularly and I endorse it for heart health. Recent analyses show positive changes.
9
Cardiovascular support
12 people found this helpful
Nattokinase is an excellent supplement for preventing heart attacks and strokes. For nine years, I have taken it and highly recommend it, especially after having experienced a heart attack and numerous TIA strokes. It is a reliable choice for supporting cardiovascular health.
9
Relieves heart pain
6 people found this helpful
After experiencing dull chest aches post-covid vaccinations, I began taking one capsule of nattokinase daily. I'm relieved the discomfort has vanished, particularly when lying on my right side. Although I didn’t get tests done, the improvement was noticeable, and I also take omega-3 supplements alongside it.
7.5
High-quality product
Overall, I like it. It aids blood pressure and circulation. For my heart condition, I use it to reduce cholesterol after heavy meals. The product is high quality, dosed correctly, and works well with aspirin to prevent future clots. I appreciate its benefits.
7.5
Improves health status
7 people found this helpful
I purchased this for my husband, who suffers from thick blood and high haemoglobin levels. Since we started using it, his health has significantly improved, alleviating headaches and heart issues. This product has been effective in thinning his blood.
8
We designed a study to explore the effectiveness of nattokinase in treating acute myocardial infarction, a condition often caused by blood clots. Thrombus formation leads to reduced blood flow, and finding effective treatments is critical for improving outcomes in heart attack patients.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
9.5
We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
References
- Shi Y, Liu C, Gui Y, Guo Y, Zhang Y, et al. A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation. Adv Healthc Mater. 2024. doi:10.1002/adhm.202402763
- Chandrasekaran SD, Vaithilingam M, Shanker R, Kumar S, Thiyur S, et al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015;8:e23567. doi:10.5812/jjm.23567
